Version 5.4
Homo sapiens Protein: PPAPDC1B
Summary
InnateDB Protein IDBP-592284.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAPDC1B
Protein Name phosphatidic acid phosphatase type 2 domain containing 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000434916
InnateDB Gene IDBG-17549 (PPAPDC1B)
Protein Structure
UniProt Annotation
Function Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma. {ECO:0000269PubMed:16261160, ECO:0000269PubMed:17590538}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:17590538}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0046839 phospholipid dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEB5
PhosphoSite PhosphoSite-Q8NEB5
TrEMBL E9PNB1
UniProt Splice Variant
Entrez Gene 84513
UniGene Hs.567619
RefSeq
HUGO HGNC:25026
OMIM 610626
CCDS
HPRD 13720
IMGT
EMBL AC087362 AF212238 BC033025 BC106014 BD418664
GenPept AAH33025 AAI06015 AAK14924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca