InnateDB Protein
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IDBP-592616.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BCLAF1
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Protein Name
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BCL2-associated transcription factor 1
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Synonyms
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bK211L9.1; BTF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000435210
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InnateDB Gene
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IDBG-96919 (BCLAF1)
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Protein Structure
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Function |
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269PubMed:18794151}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
54
[view]
|
Protein-Protein |
51
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006915
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apoptotic process
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GO:0043065
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positive regulation of apoptotic process
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GO:0043620
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regulation of DNA-dependent transcription in response to stress
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:2000144
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positive regulation of DNA-dependent transcription, initiation
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GO:2001022
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positive regulation of response to DNA damage stimulus
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GO:2001244
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positive regulation of intrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NYF8
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PhosphoSite |
PhosphoSite-Q9NYF8
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TrEMBL |
B0AZU3
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UniProt Splice Variant |
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Entrez Gene |
9774
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UniGene |
Hs.718334
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RefSeq |
NP_055554
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HUGO |
HGNC:16863
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OMIM |
612588
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CCDS |
CCDS5177
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HPRD |
16544
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IMGT |
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EMBL |
AF249273
AK315884
AL121713
BC047687
BC047887
BC056894
BC063846
BC132780
BC144281
CH471051
D79986
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GenPept |
AAF64304
AAH47687
AAH47887
AAH56894
AAH63846
AAI32781
AAI44282
BAA11481
BAF98775
CAB96722
EAW47950
EAW47951
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