Version 5.4
Homo sapiens Protein: ASIC5
Summary
InnateDB Protein IDBP-592709.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIC5
Protein Name amiloride-sensitive cation channel 5, intestinal
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000442477
InnateDB Gene IDBG-546382 (ASIC5)
Protein Structure
UniProt Annotation
Function Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. {ECO:0000269PubMed:10767424}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:10767424}; Multi-pass membrane protein {ECO:0000269PubMed:10767424}.
Disease Associations
Tissue Specificity Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum. {ECO:0000269PubMed:10767424}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005272 sodium channel activity
GO:0015252 hydrogen ion channel activity
GO:0015280 ligand-gated sodium channel activity
Biological Process
GO:0006814 sodium ion transport
GO:0015992 proton transport
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001873 Na+ channel, amiloride-sensitive
PFAM PF00858
PRINTS PR01078
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY37
PhosphoSite PhosphoSite-Q9NY37
TrEMBL
UniProt Splice Variant
Entrez Gene 51802
UniGene Hs.381349
RefSeq NP_059115
HUGO HGNC:17537
OMIM
CCDS CCDS3793
HPRD 16470
IMGT
EMBL AJ252011 CH471056
GenPept CAB85607 EAX04887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca