InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMM10

Summary

InnateDB Protein

IDBP-592763.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMM10

Protein Name

translocase of inner mitochondrial membrane 10 homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000435678

InnateDB Gene

IDBG-46728 (TIMM10)

Protein Structure

UniProt Annotation

Function

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269PubMed:14726512}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:11489896, ECO:0000269PubMed:14726512}; Peripheral membrane protein {ECO:0000269PubMed:11489896, ECO:0000269PubMed:14726512}; Intermembrane side {ECO:0000269PubMed:11489896, ECO:0000269PubMed:14726512}.

Disease Associations

Tissue Specificity

Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269PubMed:10552927, ECO:0000269PubMed:10611480}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0051087	chaperone binding

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0007605	sensory perception of sound
GO:0044267	cellular protein metabolic process
GO:0045039	protein import into mitochondrial inner membrane
GO:0072321	chaperone-mediated protein transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0005758	mitochondrial intermembrane space
GO:0042719	mitochondrial intermembrane space protein transporter complex