InnateDB Protein
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IDBP-592850.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CTBP2
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Protein Name
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C-terminal binding protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000436285
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InnateDB Gene
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IDBG-92761 (CTBP2)
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Protein Structure
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Function |
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). {ECO:0000250}.Isoform 2 probably acts as a scaffold for specialized synapses.
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Subcellular Localization |
Nucleus {ECO:0000305}. Cell junction, synapse {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
98
[view]
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Protein-Protein |
98
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0016616
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oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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GO:0051287
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NAD binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006139
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
IPR006140
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
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PFAM |
PF00389
PF02826
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P56545
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PhosphoSite |
PhosphoSite-P56545
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1488
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UniGene |
Hs.739999
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RefSeq |
XP_005269619
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HUGO |
HGNC:2495
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OMIM |
602619
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CCDS |
CCDS7643
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HPRD |
04016
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IMGT |
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EMBL |
AF016507
AF222711
AK290390
AL596261
AL731571
AL833398
BC002486
BC047018
BC052276
BC072020
BT007012
CH471066
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GenPept |
AAC39603
AAG45951
AAH02486
AAH47018
AAH52276
AAH72020
AAP35658
BAF83079
CAH10590
CAH72472
CAI16100
CAI16102
EAW49247
EAW49249
EAW49250
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