InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRPR

Summary

InnateDB Protein

IDBP-592911.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRPR

Protein Name

signal recognition particle receptor (docking protein)

Synonyms

DP; Sralpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000435508

InnateDB Gene

IDBG-75769 (SRPR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	11 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005047	signal recognition particle binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006613	cotranslational protein targeting to membrane
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0010467	gene expression
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005785	signal recognition particle receptor complex
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR003593 AAA+ ATPase domain
IPR005129 ArgK protein
IPR007222 Signal recognition particle receptor, alpha subunit, N-terminal
IPR011012 Longin-like domain
IPR013822 Signal recognition particle, SRP54 subunit, helical bundle
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00448
PF01656
PF03308
PF04086
PF02881

PRINTS

PIRSF

SMART

SM00962
SM00382
SM00963

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08240