Version 5.4
Homo sapiens Protein: ANO1
Summary
InnateDB Protein IDBP-592922.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANO1
Protein Name anoctamin 1, calcium activated chloride channel
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435797
InnateDB Gene IDBG-62055 (ANO1)
Protein Structure
UniProt Annotation
Function Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO:0000269PubMed:20056604, ECO:0000269PubMed:21984732, ECO:0000269PubMed:22178883, ECO:0000269PubMed:22946059}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.
Disease Associations
Tissue Specificity Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. {ECO:0000269PubMed:15215166, ECO:0000269PubMed:16906560}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005227 calcium activated cation channel activity
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006812 cation transport
GO:0006821 chloride transport
GO:0007275 multicellular organismal development
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007632 Anoctamin
PFAM PF04547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5XXA6
PhosphoSite PhosphoSite-Q5XXA6
TrEMBL
UniProt Splice Variant
Entrez Gene 55107
UniGene Hs.608678
RefSeq
HUGO HGNC:21625
OMIM 610108
CCDS
HPRD 18202
IMGT
EMBL AK097619 AK293088 AY728143 BC033036
GenPept AAH33036 AAU82085 BAC05123 BAF85777

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca