InnateDB Protein
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IDBP-593299.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TBC1D10C
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Protein Name
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TBC1 domain family, member 10C
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000443654
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InnateDB Gene
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IDBG-60280 (TBC1D10C)
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Protein Structure
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Function |
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. {ECO:0000269PubMed:17230191}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Most abundant in spleen and peripheral blood leukocytes. {ECO:0000269PubMed:17230191}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005097
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Rab GTPase activator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000195
Rab-GTPase-TBC domain
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PFAM |
PF00566
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PRINTS |
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PIRSF |
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SMART |
SM00164
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IV04
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PhosphoSite |
PhosphoSite-Q8IV04
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
374403
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UniGene |
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RefSeq |
NP_940919
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HUGO |
HGNC:24702
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OMIM |
610831
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CCDS |
CCDS8162
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HPRD |
13330
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IMGT |
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EMBL |
AP003419
BC035630
BC036873
BC062999
CH471076
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GenPept |
AAH36873
AAH62999
EAW74613
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