Version 5.4
Homo sapiens Protein: SYT14
Summary
InnateDB Protein IDBP-593406.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT14
Protein Name synaptotagmin XIV
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437423
InnateDB Gene IDBG-106460 (SYT14)
Protein Structure
UniProt Annotation
Function May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
Subcellular Localization Membrane {ECO:0000269PubMed:21835308}; Single-pass type III membrane protein {ECO:0000269PubMed:21835308}. Note=Localized in perinuclear and submembranous regions.
Disease Associations Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11) [MIM:614229]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR11 is associated with psychomotor retardation. {ECO:0000269PubMed:21835308}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highly expressed in fetal and adult brain tissue. {ECO:0000269PubMed:21835308}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008219 cell death
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NB59
PhosphoSite PhosphoSite-Q8NB59
TrEMBL
UniProt Splice Variant
Entrez Gene 255928
UniGene Hs.658866
RefSeq NP_001242935
HUGO HGNC:23143
OMIM 610949
CCDS CCDS58058
HPRD 11617
IMGT
EMBL AB102948 AJ617623 AJ617624 AJ617625 AJ617626 AJ617627 AK091517 AL022397 AL022399 AL513263 BC144157
GenPept BAC03682 BAC76809 CAE85109 CAE85110 CAE85111 CAE85112 CAE85113 CAI17884 CAI17885 CAI17886 CAI17887 CAI17888 CAI17889 CAI22770 CAI22771

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca