Version 5.4
Homo sapiens Protein: BBC3
Summary
InnateDB Protein IDBP-59347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BBC3
Protein Name BCL2 binding component 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000300880
InnateDB Gene IDBG-59341 (BBC3)
Protein Structure
UniProt Annotation
Function Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:11463392}. Note=Localized to the mitochondria in order to induce cytochrome c release. Isoform 3 is not found in mitochondria.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 17 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PG8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27113
UniGene Hs.467020
RefSeq NP_001120714
HUGO HGNC:17868
OMIM 605854
CCDS CCDS46128
HPRD 16165
IMGT
EMBL AC008532 AF354656 CH471126
GenPept AAK39544 EAW57467

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca