InnateDB Protein
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IDBP-59378.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TOB1
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Protein Name
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transducer of ERBB2, 1
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Synonyms
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APRO6; PIG49; TOB; TROB; TROB1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000268957
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InnateDB Gene
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IDBG-59376 (TOB1)
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Protein Structure
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Function |
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. {ECO:0000269PubMed:23236473, ECO:0000269PubMed:8632892}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
39
[view]
|
Protein-Protein |
37
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0008285
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negative regulation of cell proliferation
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GO:0009967
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positive regulation of signal transduction
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GO:0017148
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negative regulation of translation
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GO:0060212
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negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
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GO:0060213
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positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
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GO:1900153
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positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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Cellular Component |
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PDB ID |
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InterPro |
IPR002087
Anti-proliferative protein
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PFAM |
PF07742
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PRINTS |
PR00310
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PIRSF |
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SMART |
SM00099
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TIGRFAMs |
|
Modification |
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SwissProt |
P50616
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PhosphoSite |
PhosphoSite-P50616
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10140
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UniGene |
Hs.743451
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RefSeq |
NP_001230806
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HUGO |
HGNC:11979
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OMIM |
605523
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CCDS |
CCDS11576
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HPRD |
09273
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IMGT |
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EMBL |
AK313904
BC031406
BC070493
BC098415
BT019380
BT019381
CH471109
CR536487
CR541686
D38305
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GenPept |
AAH31406
AAH70493
AAH98415
AAV38187
AAV38188
BAA07423
BAG36627
CAG38726
CAG46487
EAW94577
EAW94578
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