InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU2F2

Summary

InnateDB Protein

IDBP-593878.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU2F2

Protein Name

POU class 2 homeobox 2

Synonyms

Oct-2; OCT2; OTF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000437224

InnateDB Gene

IDBG-53773 (POU2F2)

Protein Structure

UniProt Annotation

Function

Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269PubMed:1739980, ECO:0000269PubMed:2328728, ECO:0000269PubMed:2901913, ECO:0000269PubMed:2904654}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus.

Disease Associations

Tissue Specificity

Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. {ECO:0000269PubMed:2904654, ECO:0000269PubMed:3072196}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006959	humoral immune response

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000327 POU-specific
IPR000972 Octamer-binding transcription factor
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00029
PR00028

PIRSF

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt