InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERCC2

Summary

InnateDB Protein

IDBP-593965.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC2

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 2

Synonyms

COFS2; EM9; TFIIH; TTD; XPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000431229

InnateDB Gene

IDBG-57385 (ERCC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0043139	5'-3' DNA helicase activity
GO:0046872	metal ion binding
GO:0047485	protein N-terminus binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0007059	chromosome segregation
GO:0009650	UV protection
GO:0010467	gene expression
GO:0016032	viral process
GO:0032508	DNA duplex unwinding
GO:0033683	nucleotide-excision repair, DNA incision
GO:0035315	hair cell differentiation
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription
GO:1901990	regulation of mitotic cell cycle phase transition

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005675	holo TFIIH complex
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0071817	MMXD complex

Protein Structure and Domains

PDB ID

InterPro

IPR006554 Helicase-like, DEXD box c2 type
IPR010614 DEAD2
IPR010643 Domain of unknown function DUF1227
IPR013020 DNA helicase (DNA repair), Rad3 type
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF06733
PF06777

PRINTS

PIRSF

SMART

SM00488

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18074