Homo sapiens Protein: SV2B
Summary
InnateDB Protein IDBP-594065.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SV2B
Protein Name synaptic vesicle glycoprotein 2B
Synonyms HsT19680;
Species Homo sapiens
Ensembl Protein ENSP00000450992
InnateDB Gene IDBG-30872 (SV2B)
Protein Structure
UniProt Annotation
Function Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin- secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0055085 transmembrane transport
Cellular Component
GO:0001669 acrosomal vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
IPR022308 Synaptic vesicle protein SV2
PFAM PF00083
PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L1I2
PhosphoSite PhosphoSite-Q7L1I2
TrEMBL
UniProt Splice Variant
Entrez Gene 9899
UniGene Hs.722417
RefSeq
HUGO HGNC:16874
OMIM 185861
CCDS CCDS10370
HPRD 11765
IMGT
EMBL AB018278 AC123784 AC127520 AK294902 BC030011 CH471101 CR457086 FJ515843
GenPept AAH30011 ACS13737 BAA34455 BAG57991 CAG33367 EAX02143