InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLYAT

Summary

InnateDB Protein

IDBP-594089.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLYAT

Protein Name

glycine-N-acyltransferase

Synonyms

ACGNAT; CAT; GAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000431688

InnateDB Gene

IDBG-47902 (GLYAT)

Protein Structure

UniProt Annotation

Function

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269PubMed:22475485, ECO:0000269PubMed:7802672}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:22475485}.

Disease Associations

Tissue Specificity

Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269PubMed:22475485}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016746	transferase activity, transferring acyl groups
GO:0047961	glycine N-acyltransferase activity
GO:0047962	glycine N-benzoyltransferase activity

Biological Process

GO:0006544	glycine metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009636	response to toxic substance
GO:0032787	monocarboxylic acid metabolic process
GO:0044281	small molecule metabolic process