InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EHF

Summary

InnateDB Protein

IDBP-594191.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHF

Protein Name

ets homologous factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000433508

InnateDB Gene

IDBG-39419 (EHF)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. {ECO:0000269PubMed:10527851, ECO:0000269PubMed:10644770, ECO:0000269PubMed:11259407, ECO:0000269PubMed:12444029, ECO:0000269PubMed:17027647}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237, ECO:0000269PubMed:11259407, ECO:0000269PubMed:12444029}.

Disease Associations

Tissue Specificity

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes. {ECO:0000269PubMed:10527851, ECO:0000269PubMed:10644770, ECO:0000269PubMed:11259407, ECO:0000269PubMed:12444029}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0030855	epithelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter