Homo sapiens Protein: NFATC4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-594696.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | NFATC4 | ||||||||||||||||||||||
Protein Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | ||||||||||||||||||||||
Synonyms | NF-AT3; NF-ATC4; NFAT3; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000450644 | ||||||||||||||||||||||
InnateDB Gene | IDBG-3927 (NFATC4) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. {ECO:0000269PubMed:11997522, ECO:0000269PubMed:17213202, ECO:0000269PubMed:18668201, ECO:0000269PubMed:7749981}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:18347059}. Nucleus {ECO:0000269PubMed:18347059}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. {ECO:0000269PubMed:18675896}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR002909
IPT domain IPR008366 Nuclear factor of activated T cells (NFAT) IPR008967 p53-like transcription factor, DNA-binding IPR011539 Rel homology domain IPR014756 Immunoglobulin E-set |
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PFAM |
PF01833
PF00554 |
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PRINTS |
PR01789
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PIRSF | |||||||||||||||||||||||
SMART |
SM00429
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q14934 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q14934 | ||||||||||||||||||||||
TrEMBL | G3V4K1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 4776 | ||||||||||||||||||||||
UniGene | Hs.77810 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:7778 | ||||||||||||||||||||||
OMIM | 602699 | ||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | 09096 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK293185 AK302271 AL096870 BC008857 BC053855 EU887632 EU887633 EU887634 EU887635 EU887636 EU887637 EU887638 EU887639 EU887640 EU887641 EU887642 EU887643 EU887644 EU887645 EU887646 EU887647 EU887648 EU887649 EU887650 EU887651 EU887652 EU887653 EU887654 EU887655 L41066 | ||||||||||||||||||||||
GenPept | AAA79175 AAH08857 AAH53855 ACG55652 ACG55653 ACG55654 ACG55655 ACG55656 ACG55657 ACG55658 ACG55659 ACG55660 ACG55661 ACG55662 ACG55663 ACG55664 ACG55665 ACG55666 ACG55667 ACG55668 ACG55669 ACG55670 ACG55671 ACG55672 ACG55673 ACG55674 ACG55675 BAG56726 BAG63617 | ||||||||||||||||||||||