InnateDB Protein
|
IDBP-595094.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CPM
|
Protein Name
|
carboxypeptidase M
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000447255
|
InnateDB Gene
|
IDBG-46841 (CPM)
|
Protein Structure
|
|
Function |
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. {ECO:0000269PubMed:12457462}.
|
Subcellular Localization |
Cell membrane {ECO:0000269PubMed:12457462}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:12457462}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000834
Peptidase M14, carboxypeptidase A
IPR007036
Succinylglutamate desuccinylase/aspartoacylase
IPR008969
Carboxypeptidase-like, regulatory domain
|
PFAM |
PF00246
PF04952
|
PRINTS |
PR00765
|
PIRSF |
PIRSF039012
|
SMART |
SM00631
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P14384
|
PhosphoSite |
PhosphoSite-P14384
|
TrEMBL |
H0YHG6
|
UniProt Splice Variant |
|
Entrez Gene |
1368
|
UniGene |
Hs.731804
|
RefSeq |
NP_001865
|
HUGO |
HGNC:2311
|
OMIM |
114860
|
CCDS |
CCDS8987
|
HPRD |
00273
|
IMGT |
|
EMBL |
AC025423
AC133749
AF262940
AF262941
AF262942
AF262943
AF262944
AF262945
AF262946
AF262947
AF368463
AK313180
BC022276
J04970
|
GenPept |
AAA35651
AAG47641
AAH22276
AAK69717
BAG35997
|
|
|