InnateDB Protein
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IDBP-595122.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NFATC4
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Protein Name
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nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
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Synonyms
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NF-AT3; NF-ATC4; NFAT3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000451496
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InnateDB Gene
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IDBG-3927 (NFATC4)
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Protein Structure
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Function |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. {ECO:0000269PubMed:11997522, ECO:0000269PubMed:17213202, ECO:0000269PubMed:18668201, ECO:0000269PubMed:7749981}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18347059}. Nucleus {ECO:0000269PubMed:18347059}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
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Disease Associations |
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Tissue Specificity |
Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. {ECO:0000269PubMed:18675896}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14934
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PhosphoSite |
PhosphoSite-Q14934
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4776
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UniGene |
Hs.77810
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RefSeq |
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HUGO |
HGNC:7778
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OMIM |
602699
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CCDS |
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HPRD |
09096
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IMGT |
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EMBL |
AK293185
AK302271
BC008857
BC053855
EU887632
EU887633
EU887634
EU887635
EU887636
EU887637
EU887638
EU887639
EU887640
EU887641
EU887642
EU887643
EU887644
EU887645
EU887646
EU887647
EU887648
EU887649
EU887650
EU887651
EU887652
EU887653
EU887654
EU887655
L41066
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GenPept |
AAA79175
AAH08857
AAH53855
ACG55652
ACG55653
ACG55654
ACG55655
ACG55656
ACG55657
ACG55658
ACG55659
ACG55660
ACG55661
ACG55662
ACG55663
ACG55664
ACG55665
ACG55666
ACG55667
ACG55668
ACG55669
ACG55670
ACG55671
ACG55672
ACG55673
ACG55674
ACG55675
BAG56726
BAG63617
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