Version 5.4
Homo sapiens Protein: TXNRD1
Summary
InnateDB Protein IDBP-595658.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNRD1
Protein Name thioredoxin reductase 1
Synonyms GRIM-12; TR; TR1; TRXR1; TXNR;
Species Homo sapiens
Ensembl Protein ENSP00000436229
InnateDB Gene IDBG-54357 (TXNRD1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0008033 tRNA processing
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002218 Glucose-inhibited division protein A-related
IPR002938 Monooxygenase, FAD-binding
IPR003953 FAD binding domain
IPR004792 Conserved hypothetical protein CHP00275, flavoprotein HI0933-like
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
PFAM PF01134
PF01494
PF00890
PF03486
PF07992
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PQI3
UniProt Splice Variant
Entrez Gene 7296
UniGene Hs.741567
RefSeq
HUGO HGNC:12437
OMIM 601112
CCDS
HPRD 03068
IMGT
EMBL AC089983 AC090107
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca