InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHMT2

Summary

InnateDB Protein

IDBP-595928.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHMT2

Protein Name

serine hydroxymethyltransferase 2 (mitochondrial)

Synonyms

GLYA; HEL-S-51e; SHMT;

Species

Homo sapiens

Ensembl Protein

ENSP00000452419

InnateDB Gene

IDBG-42369 (SHMT2)

Protein Structure

UniProt Annotation

Function

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. {ECO:0000269PubMed:21876188}.

Subcellular Localization

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004372	glycine hydroxymethyltransferase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006544	glycine metabolic process
GO:0006563	L-serine metabolic process
GO:0006730	one-carbon metabolic process
GO:0035999	tetrahydrofolate interconversion

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0015630	microtubule cytoskeleton
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome