InnateDB Protein
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IDBP-596100.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AMBRA1
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Protein Name
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autophagy/beclin-1 regulator 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433945
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InnateDB Gene
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IDBG-41755 (AMBRA1)
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Protein Structure
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Function |
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
47
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q9C0C7
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PhosphoSite |
PhosphoSite-Q9C0C7
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TrEMBL |
E9PL55
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UniProt Splice Variant |
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Entrez Gene |
55626
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UniGene |
Hs.738748
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RefSeq |
XP_005253068
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HUGO |
HGNC:25990
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OMIM |
611359
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CCDS |
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HPRD |
10975
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IMGT |
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EMBL |
AB051523
AC024293
AC115097
AC116021
AC127035
AK000301
AK023197
AL834190
BC045609
CH471064
DQ870924
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GenPept |
AAH45609
ABI74670
BAA91067
BAB14457
BAB21827
EAW67996
EAW67999
EAW68001
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