InnateDB Protein
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IDBP-59616.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NME1
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Protein Name
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non-metastatic cells 1, protein (NM23A) expressed in
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Synonyms
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AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000013034
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InnateDB Gene
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IDBG-409263 (NME1)
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Protein Structure
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Function |
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269PubMed:12628186, ECO:0000269PubMed:16818237, ECO:0000269PubMed:8810265}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16442775}. Nucleus {ECO:0000269PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. {ECO:0000269PubMed:10512675, ECO:0000269PubMed:12601555, ECO:0000269PubMed:16442775}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
67
[view]
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Protein-Protein |
63
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001564
Nucleoside diphosphate kinase
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PFAM |
PF00334
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PRINTS |
PR01243
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PIRSF |
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SMART |
SM00562
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TIGRFAMs |
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Modification |
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SwissProt |
P15531
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PhosphoSite |
PhosphoSite-P15531
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TrEMBL |
E7ERL0
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UniProt Splice Variant |
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Entrez Gene |
4830
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UniGene |
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RefSeq |
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HUGO |
HGNC:7849
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OMIM |
156490
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CCDS |
CCDS11578
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HPRD |
01131
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IMGT |
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EMBL |
AC005839
AF487339
AK291105
BC000293
BC018994
CH471109
CR542104
CR542115
X17620
X73066
X75598
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GenPept |
AAH00293
AAH18994
AAO85436
BAF83794
CAA35621
CAA51527
CAA53270
CAG46901
CAG46912
EAW94568
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