InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: B2M

Summary

InnateDB Protein

IDBP-596485.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B2M

Protein Name

beta-2-microglobulin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000453350

InnateDB Gene

IDBG-9902 (B2M)

Protein Structure

UniProt Annotation

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subcellular Localization

Secreted {ECO:0000269PubMed:1336137, ECO:0000269PubMed:7554280}. Note=Detected in serum and urine.

Disease Associations

Hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]: Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. {ECO:0000269PubMed:16549777}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	188 [view]
Protein-Protein	175 [view]
Protein-DNA	9 [view]
Protein-RNA	4 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001895	retina homeostasis
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response
GO:0050690	regulation of defense response to virus by virus
GO:0050776	regulation of immune response
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane
GO:0031905	early endosome lumen
GO:0042612	MHC class I protein complex
GO:0070062	extracellular vesicular exosome