InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MELK

Summary

InnateDB Protein

IDBP-596496.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MELK

Protein Name

maternal embryonic leucine zipper kinase

Synonyms

HPK38;

Species

Homo sapiens

Ensembl Protein

ENSP00000439792

InnateDB Gene

IDBG-65356 (MELK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0008283	cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030097	hemopoiesis
GO:0043065	positive regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0061351	neural precursor cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001772 Kinase associated domain 1 (KA1)
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028375 KA1 domain/Ssp2 C-terminal domain

PFAM

PF00069
PF07714
PF02149

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt