InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGFBR1

Summary

InnateDB Protein

IDBP-596508.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFBR1

Protein Name

transforming growth factor, beta receptor 1

Synonyms

AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TGFR-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000447707

InnateDB Gene

IDBG-78488 (TGFBR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 369 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	369 [view]
Protein-Protein	366 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005524	ATP binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009435	NAD biosynthetic process
GO:0023014	signal transduction by phosphorylation

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
IPR003605 TGF beta receptor, GS motif

PFAM

PF01064
PF01729
PF08515

PRINTS

PIRSF

SMART

SM00467

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite