InnateDB Protein
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IDBP-596788.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DND1
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Protein Name
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dead end homolog 1 (zebrafish)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000445366
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InnateDB Gene
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IDBG-547469 (DND1)
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Protein Structure
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Function |
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18155131}. Cytoplasm {ECO:0000269PubMed:18155131}. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IYX4
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PhosphoSite |
PhosphoSite-Q8IYX4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
373863
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UniGene |
Hs.741051
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RefSeq |
NP_919225
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HUGO |
HGNC:23799
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OMIM |
609385
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CCDS |
CCDS4236
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HPRD |
13240
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IMGT |
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EMBL |
AY321065
BC033496
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GenPept |
AAH33496
AAQ63635
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