InnateDB Protein
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IDBP-596806.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDE8A
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Protein Name
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phosphodiesterase 8A
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Synonyms
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HsT19550;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432309
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InnateDB Gene
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IDBG-27887 (PDE8A)
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Protein Structure
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Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. {ECO:0000269PubMed:18983167}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000156
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two-component response regulator activity
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GO:0004114
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3',5'-cyclic-nucleotide phosphodiesterase activity
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001789
Signal transduction response regulator, receiver domain
IPR011006
CheY-like superfamily
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PFAM |
PF00072
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PRINTS |
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PIRSF |
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SMART |
SM00448
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TIGRFAMs |
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Modification |
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SwissProt |
O60658
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PhosphoSite |
PhosphoSite-O60658
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5151
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UniGene |
Hs.9333
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RefSeq |
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HUGO |
HGNC:8793
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OMIM |
602972
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CCDS |
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HPRD |
09114
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IMGT |
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EMBL |
AC027078
AC087468
AF056490
AF332653
AF388183
AF388184
AF388185
AF388186
AF388187
AK074280
AK127232
AL109687
AL109778
BC060762
BC075822
CH471101
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GenPept |
AAC39763
AAH60762
AAH75822
AAK57641
AAL18610
AAL18611
AAL18612
AAL18613
AAL18614
BAG54458
CAB52020
CAB52432
EAX01967
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