Version 5.4
Homo sapiens Protein: PTPRO
Summary
InnateDB Protein IDBP-597157.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRO
Protein Name protein tyrosine phosphatase, receptor type, O
Synonyms GLEPP1; NPHS6; PTP-OC; PTP-U2; PTPROT; PTPU2; R-PTP-O;
Species Homo sapiens
Ensembl Protein ENSP00000444173
InnateDB Gene IDBG-21457 (PTPRO)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0017147 Wnt-protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0002548 monocyte chemotaxis
GO:0003093 regulation of glomerular filtration
GO:0003105 negative regulation of glomerular filtration
GO:0006470 protein dephosphorylation
GO:0007411 axon guidance
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010977 negative regulation of neuron projection development
GO:0030032 lamellipodium assembly
GO:0032835 glomerulus development
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0036060 slit diaphragm assembly
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090260 negative regulation of retinal ganglion cell axon guidance
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
PFAM PF00041
PF01108
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16827
PhosphoSite PhosphoSite-Q16827
TrEMBL
UniProt Splice Variant
Entrez Gene 5800
UniGene Hs.160871
RefSeq
HUGO HGNC:9678
OMIM 600579
CCDS
HPRD 02784
IMGT
EMBL AC007542 AC022334 AC092183 AF187043 AF187044 AK290982 BC035960 BC126201 BC126203 CH471094 U20489 Z48541
GenPept AAA82892 AAF04086 AAF04087 AAH35960 AAI26202 AAI26204 BAF83671 CAA88425 EAW96349 EAW96350 EAW96351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca