InnateDB Protein
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IDBP-597267.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKAP13
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Protein Name
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A kinase (PRKA) anchor protein 13
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Synonyms
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AKAP-13; AKAP-Lbc; ARHGEF13; BRX; c-lbc; HA-3; Ht31; LBC; p47; PRKA13; PROTO-LB; PROTO-LBC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000453634
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InnateDB Gene
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IDBG-28095 (AKAP13)
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Protein Structure
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Function |
Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. {ECO:0000269PubMed:11546812, ECO:0000269PubMed:11579095, ECO:0000269PubMed:9627117, ECO:0000269PubMed:9891067}.
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Subcellular Localization |
Cytoplasm. Nucleus. Membrane.
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Disease Associations |
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Tissue Specificity |
Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen- responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. {ECO:0000269PubMed:11546812, ECO:0000269PubMed:9627117, ECO:0000269PubMed:9891067}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006468
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protein phosphorylation
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GO:0007264
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small GTPase mediated signal transduction
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GO:0032321
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positive regulation of Rho GTPase activity
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GO:0035023
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regulation of Rho protein signal transduction
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GO:0043065
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positive regulation of apoptotic process
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0051056
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regulation of small GTPase mediated signal transduction
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GO:0097190
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apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q12802
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PhosphoSite |
PhosphoSite-Q12802
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TrEMBL |
H0YMI5
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UniProt Splice Variant |
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Entrez Gene |
11214
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UniGene |
Hs.741394
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RefSeq |
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HUGO |
HGNC:371
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OMIM |
604686
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CCDS |
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HPRD |
05253
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IMGT |
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EMBL |
AB055890
AB209414
AC021739
AC087286
AC104046
AC110592
AF126008
AF127481
AF387101
AF406992
BC050312
M90360
U03634
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GenPept |
AAA58670
AAC50065
AAD21311
AAD40799
AAH50312
AAL11723
AAL40923
BAB62913
BAD92651
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