InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC1A5

Summary

InnateDB Protein

IDBP-598241.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC1A5

Protein Name

solute carrier family 1 (neutral amino acid transporter), member 5

Synonyms

AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;

Species

Homo sapiens

Ensembl Protein

ENSP00000444408

InnateDB Gene

IDBG-59011 (SLC1A5)

Protein Structure

UniProt Annotation

Function

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349). {ECO:0000269PubMed:10051606, ECO:0000269PubMed:10196349, ECO:0000269PubMed:10708449, ECO:0000269PubMed:23492904}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0015171	amino acid transmembrane transporter activity
GO:0015175	neutral amino acid transmembrane transporter activity
GO:0015186	L-glutamine transmembrane transporter activity
GO:0015194	L-serine transmembrane transporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006811	ion transport
GO:0006835	dicarboxylic acid transport
GO:0006860	extracellular amino acid transport
GO:0006865	amino acid transport
GO:0006868	glutamine transport
GO:0009615	response to virus
GO:0015804	neutral amino acid transport
GO:0015825	L-serine transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome