InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OCLN

Summary

InnateDB Protein

IDBP-598373.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OCLN

Protein Name

occludin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445940

InnateDB Gene

IDBG-26117 (OCLN)

Protein Structure

UniProt Annotation

Function

May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269PubMed:19114660}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell junction, tight junction.

Disease Associations

Band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:251290]: A neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay. {ECO:0000269PubMed:20727516}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	31 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006461	protein complex assembly
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle