InnateDB Protein
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IDBP-5985.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF3D
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Protein Name
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eukaryotic translation initiation factor 3, subunit D
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Synonyms
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eIF3-p66; eIF3-zeta; EIF3S7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000216190
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InnateDB Gene
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IDBG-5983 (EIF3D)
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Protein Structure
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Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03003}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
83
[view]
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Protein-Protein |
82
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007783
Eukaryotic translation initiation factor 3 subunit D
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PFAM |
PF05091
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PRINTS |
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PIRSF |
PIRSF016281
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15371
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PhosphoSite |
PhosphoSite-O15371
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TrEMBL |
B4E1K8
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UniProt Splice Variant |
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Entrez Gene |
8664
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UniGene |
Hs.55682
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RefSeq |
NP_003744
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HUGO |
HGNC:3278
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OMIM |
603915
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CCDS |
CCDS13930
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HPRD |
04888
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IMGT |
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EMBL |
AK300199
AK303884
AK312939
AL022313
BC000328
BC000469
BC014912
BC080515
BC093100
BC093686
BC101477
BT007381
CH471095
CR456489
U54558
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GenPept |
AAD03466
AAH00328
AAH00469
AAH14912
AAH80515
AAH93100
AAH93686
AAI01478
AAP36045
BAG35781
BAG61970
BAG64820
CAA18440
CAG30375
EAW60109
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