Version 5.4
Homo sapiens Protein: TMEM30B
Summary
InnateDB Protein IDBP-598606.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM30B
Protein Name transmembrane protein 30B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000450842
InnateDB Gene IDBG-8453 (TMEM30B)
Protein Structure
UniProt Annotation
Function Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. {ECO:0000269PubMed:20961850, ECO:0000305}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:20961850}; Multi-pass membrane protein {ECO:0000269PubMed:20961850}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006869 lipid transport
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005045 CDC50/LEM3 family
PFAM PF03381
PRINTS
PIRSF PIRSF015840
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MIR4
PhosphoSite PhosphoSite-Q3MIR4
TrEMBL
UniProt Splice Variant
Entrez Gene 161291
UniGene Hs.712330
RefSeq NP_001017970
HUGO HGNC:27254
OMIM 611029
CCDS CCDS32093
HPRD 18567
IMGT
EMBL AK091169 BC101726 BC113559 CH471061
GenPept AAI01727 AAI13560 BAG52296 EAW80799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca