InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMPD1

Summary

InnateDB Protein

IDBP-598676.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMPD1

Protein Name

sphingomyelin phosphodiesterase 1, acid lysosomal

Synonyms

ASM; ASMASE; NPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000435350

InnateDB Gene

IDBG-28681 (SMPD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006684	sphingomyelin metabolic process
GO:0006685	sphingomyelin catabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0008219	cell death
GO:0023021	termination of signal transduction
GO:0035307	positive regulation of protein dephosphorylation
GO:0043407	negative regulation of MAP kinase activity
GO:0044281	small molecule metabolic process
GO:0046513	ceramide biosynthetic process

Cellular Component

GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PIRSF

PIRSF000948

SMART

SM00741

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt