InnateDB Protein
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IDBP-598885.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TWF1
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Protein Name
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twinfilin, actin-binding protein, homolog 1 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000449428
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InnateDB Gene
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IDBG-28090 (TWF1)
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Protein Structure
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Function |
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. {ECO:0000269PubMed:7507208}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002108
Actin-depolymerising factor homology domain
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PFAM |
PF00241
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PRINTS |
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PIRSF |
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SMART |
SM00102
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TIGRFAMs |
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Modification |
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SwissProt |
Q12792
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PhosphoSite |
PhosphoSite-Q12792
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5756
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UniGene |
Hs.313056
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RefSeq |
NP_001229326
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HUGO |
HGNC:9620
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OMIM |
610932
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CCDS |
CCDS55818
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HPRD |
10174
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IMGT |
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EMBL |
AB209302
AK127868
AK291223
AK297206
BC022344
BC043148
BC068548
BT019691
CR541736
CR541761
U02680
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GenPept |
AAC50062
AAH22344
AAH43148
AAH68548
AAV38497
BAD92539
BAF83912
BAG54588
BAG59691
CAG46536
CAG46561
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