InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRBK1

Summary

InnateDB Protein

IDBP-59898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRBK1

Protein Name

adrenergic, beta, receptor kinase 1

Synonyms

BARK1; BETA-ARK1; GRK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000312262

InnateDB Gene

IDBG-59896 (ADRBK1)

Protein Structure

UniProt Annotation

Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. {ECO:0000269PubMed:19306925}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in peripheral blood leukocytes. {ECO:0000269PubMed:10085131}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031694	alpha-2A adrenergic receptor binding
GO:0031755	Edg-2 lysophosphatidic acid receptor binding
GO:0047696	beta-adrenergic receptor kinase activity

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0003108	negative regulation of the force of heart contraction by chemical signal
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway
GO:0007507	heart development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0031623	receptor internalization
GO:0033605	positive regulation of catecholamine secretion
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0045087	innate immune response
GO:0045988	negative regulation of striated muscle contraction
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000239 GPCR kinase
IPR000342 Regulator of G protein signalling domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016137 Regulator of G protein signalling superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00615
PF00069
PF07714
PF00169

PRINTS

PR00717
PR01301
PR00109

PIRSF

SMART

SM00133
SM00233
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt