InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AURKB

Summary

InnateDB Protein

IDBP-599743.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AURKB

Protein Name

aurora kinase B

Synonyms

AIK2; AIM-1; AIM1; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK12; STK5;

Species

Homo sapiens

Ensembl Protein

ENSP00000443869

InnateDB Gene

IDBG-28278 (AURKB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 203 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	203 [view]
Protein-Protein	195 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035174	histone serine kinase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0002903	negative regulation of B cell apoptotic process
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0009838	abscission
GO:0016570	histone modification
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031565	cytokinesis checkpoint
GO:0031577	spindle checkpoint
GO:0032091	negative regulation of protein binding
GO:0032466	negative regulation of cytokinesis
GO:0032467	positive regulation of cytokinesis
GO:0034501	protein localization to kinetochore
GO:0034644	cellular response to UV
GO:0036089	cleavage furrow formation
GO:0043146	spindle stabilization
GO:0043988	histone H3-S28 phosphorylation
GO:0046777	protein autophosphorylation
GO:0051256	spindle midzone assembly involved in mitosis
GO:0051983	regulation of chromosome segregation

Cellular Component

GO:0000779	condensed chromosome, centromeric region
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005819	spindle
GO:0005829	cytosol
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt