InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARD3

Summary

InnateDB Protein

IDBP-600012.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARD3

Protein Name

par-3 partitioning defective 3 homolog (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000440857

InnateDB Gene

IDBG-69007 (PARD3)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. {ECO:0000250, ECO:0000269PubMed:19812038}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endomembrane system {ECO:0000269PubMed:20332120}. Cell junction {ECO:0000269PubMed:20332120}. Cell junction, tight junction {ECO:0000269PubMed:20332120}. Cell membrane {ECO:0000269PubMed:20332120}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:20332120}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheat (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:12234671}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	87 [view]
Protein-Protein	87 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding

Biological Process

GO:0006461	protein complex assembly
GO:0006612	protein targeting to membrane
GO:0007049	cell cycle
GO:0007163	establishment or maintenance of cell polarity
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007409	axonogenesis
GO:0008356	asymmetric cell division
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0022011	myelination in peripheral nervous system
GO:0031643	positive regulation of myelination
GO:0034329	cell junction assembly
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly
GO:0090162	establishment of epithelial cell polarity

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0012505	endomembrane system
GO:0030054	cell junction
GO:0033269	internode region of axon