Homo sapiens Protein: DIO2
Summary
InnateDB Protein IDBP-600416.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIO2
Protein Name deiodinase, iodothyronine, type II
Synonyms 5DII; D2; DIOII; SelY; TXDI2;
Species Homo sapiens
Ensembl Protein ENSP00000450980
InnateDB Gene IDBG-14346 (DIO2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004800 thyroxine 5'-deiodinase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0042404 thyroid hormone catabolic process
GO:0042446 hormone biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000643 Iodothyronine deiodinase
IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
PFAM PF00837
PF00578
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF PIRSF001330
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9C0K2
UniProt Splice Variant
Entrez Gene 1734
UniGene Hs.732170
RefSeq NP_001007024
HUGO HGNC:2884
OMIM 601413
CCDS CCDS55934
HPRD 09027
IMGT
EMBL AB039888 AC007372 AC010849 AL049837 CH471061
GenPept BAB21594 EAW81322 EAW81325