Version 5.4
Homo sapiens Protein: GNG2
Summary
InnateDB Protein IDBP-600551.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNG2
Protein Name guanine nucleotide binding protein (G protein), gamma 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000451576
InnateDB Gene IDBG-6595 (GNG2)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain. {ECO:0000269PubMed:10833460}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0031681 G-protein beta-subunit binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0044281 small molecule metabolic process
GO:0071377 cellular response to glucagon stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071870 cellular response to catecholamine stimulus
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain
PFAM PF00631
PRINTS PR00321
PIRSF
SMART SM00224
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59768
PhosphoSite PhosphoSite-P59768
TrEMBL
UniProt Splice Variant
Entrez Gene 54331
UniGene Hs.741081
RefSeq XP_006720236
HUGO HGNC:4404
OMIM 606981
CCDS CCDS32082
HPRD 16234
IMGT
EMBL AF493870 AL832878 BC020774 BC060856 CH471078
GenPept AAH20774 AAH60856 AAM12584 CAI46198 EAW65663

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca