InnateDB Protein
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IDBP-600770.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRKAB1
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Protein Name
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protein kinase, AMP-activated, beta 1 non-catalytic subunit
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Synonyms
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AMPK; HAMPKb;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441369
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InnateDB Gene
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IDBG-59969 (PRKAB1)
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Protein Structure
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Function |
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
40
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006828
5-AMP-activated protein kinase, beta subunit, interaction domain
IPR014756
Immunoglobulin E-set
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PFAM |
PF04739
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PRINTS |
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PIRSF |
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SMART |
SM01010
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y478
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PhosphoSite |
PhosphoSite-Q9Y478
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TrEMBL |
F5H610
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UniProt Splice Variant |
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Entrez Gene |
5564
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UniGene |
Hs.741184
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RefSeq |
XP_005253966
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HUGO |
HGNC:9378
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OMIM |
602740
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CCDS |
CCDS9191
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HPRD |
04116
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IMGT |
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EMBL |
AC002563
AF022116
AJ224515
AK301165
BC001007
BC001056
BC001823
BC017671
CH471054
U83994
U87271
U87272
U87273
U87274
U87275
U87276
Y12556
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GenPept |
AAB71326
AAC98897
AAD00625
AAD09237
AAH01007
AAH01056
AAH01823
AAH17671
BAG62754
CAA12024
CAA73146
EAW98151
EAW98152
EAW98153
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