InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP2

Summary

InnateDB Protein

IDBP-600858.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP2

Protein Name

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Synonyms

CLG4; CLG4A; MMP-II; MONA; TBE-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000444143

InnateDB Gene

IDBG-31271 (MMP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000562 Fibronectin, type II, collagen-binding
IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR013806 Kringle-like fold
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00040
PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

SMART

SM00059
SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt