InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CFL1

Summary

InnateDB Protein

IDBP-600967.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFL1

Protein Name

cofilin 1 (non-muscle)

Synonyms

CFL; HEL-S-15;

Species

Homo sapiens

Ensembl Protein

ENSP00000432660

InnateDB Gene

IDBG-57818 (CFL1)

Protein Structure

UniProt Annotation

Function

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. {ECO:0000269PubMed:15580268, ECO:0000269PubMed:21834987, ECO:0000269PubMed:23633677}.

Subcellular Localization

Nucleus matrix {ECO:0000269PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269PubMed:15580268}; Peripheral membrane protein {ECO:0000269PubMed:15580268}; Cytoplasmic side {ECO:0000269PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269PubMed:15580268}; Peripheral membrane protein {ECO:0000269PubMed:15580268}; Cytoplasmic side {ECO:0000269PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Disease Associations

Tissue Specificity

Widely distributed in various tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	92 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0001755	neural crest cell migration
GO:0001842	neural fold formation
GO:0002576	platelet degranulation
GO:0006468	protein phosphorylation
GO:0006928	cellular component movement
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0007266	Rho protein signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0009615	response to virus
GO:0022604	regulation of cell morphogenesis
GO:0030010	establishment of cell polarity
GO:0030036	actin cytoskeleton organization
GO:0030042	actin filament depolymerization
GO:0030168	platelet activation
GO:0030836	positive regulation of actin filament depolymerization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043066	negative regulation of apoptotic process
GO:0043200	response to amino acid
GO:0045087	innate immune response

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030864	cortical actin cytoskeleton
GO:0031258	lamellipodium membrane
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome