InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAOX

Summary

InnateDB Protein

IDBP-601562.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAOX

Protein Name

polyamine oxidase (exo-N4-amino)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000432737

InnateDB Gene

IDBG-93753 (PAOX)

Protein Structure

UniProt Annotation

Function

Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.

Subcellular Localization

Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. {ECO:0000269PubMed:12477380}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0046592	polyamine oxidase activity
GO:0052899	N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity
GO:0052902	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
GO:0052903	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052904	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity

Biological Process

GO:0006595	polyamine metabolic process
GO:0006596	polyamine biosynthetic process
GO:0006598	polyamine catabolic process
GO:0006805	xenobiotic metabolic process
GO:0009446	putrescine biosynthetic process
GO:0009447	putrescine catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046203	spermidine catabolic process
GO:0046208	spermine catabolic process
GO:0055114	oxidation-reduction process
GO:1901307	positive regulation of spermidine biosynthetic process