Version 5.4
Homo sapiens Protein: ZWILCH
Summary
InnateDB Protein IDBP-601891.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZWILCH
Protein Name Zwilch, kinetochore associated, homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437749
InnateDB Gene IDBG-18211 (ZWILCH)
Protein Structure
UniProt Annotation
Function Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. {ECO:0000269PubMed:15824131}.
Subcellular Localization Chromosome, centromere, kinetochore {ECO:0000269PubMed:20462495}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007093 mitotic cell cycle checkpoint
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR018630 RZZ complex, subunit zwilch
PFAM PF09817
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H900
PhosphoSite PhosphoSite-Q9H900
TrEMBL H3BSG1
UniProt Splice Variant
Entrez Gene 55055
UniGene Hs.585062
RefSeq
HUGO HGNC:25468
OMIM 609984
CCDS CCDS73746
HPRD 07640
IMGT
EMBL AC116913 AK000898 AK023175 AK027468 AK122787 BC036900 BC090041 BX640701 CH471082
GenPept AAH36900 AAH90041 BAB14446 BAB55133 BAG53730 CAE45821 EAW77779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca