Version 5.4
Homo sapiens Protein: PUS3
Summary
InnateDB Protein IDBP-602091.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUS3
Protein Name pseudouridylate synthase 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432386
InnateDB Gene IDBG-75686 (PUS3)
Protein Structure
UniProt Annotation
Function Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001406 Pseudouridine synthase I, TruA
IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain
IPR020103 Pseudouridine synthase, catalytic domain
PFAM PF01416
PRINTS
PIRSF PIRSF001430
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZE2
PhosphoSite PhosphoSite-Q9BZE2
TrEMBL E9PRI9
UniProt Splice Variant
Entrez Gene 83480
UniGene Hs.660922
RefSeq
HUGO HGNC:25461
OMIM
CCDS CCDS8466
HPRD 15195
IMGT
EMBL AF325689 AK055702 AK314251 AP000842 BC004822 BC013427
GenPept AAG50280 AAH04822 AAH13427 BAB70990 BAG36917

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca