InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNG2

Summary

InnateDB Protein

IDBP-6022.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNG2

Protein Name

calcium channel, voltage-dependent, gamma subunit 2

Synonyms

MRD10;

Species

Homo sapiens

Ensembl Protein

ENSP00000300105

InnateDB Gene

IDBG-6020 (CACNG2)

Protein Structure

UniProt Annotation

Function

Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269PubMed:20805473}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Mental retardation, autosomal dominant 10 (MRD10) [MIM:614256]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:21376300}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0006810	transport
GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0019226	transmission of nerve impulse
GO:0042391	regulation of membrane potential
GO:0050877	neurological system process
GO:0051899	membrane depolarization
GO:0060081	membrane hyperpolarization
GO:0070588	calcium ion transmembrane transport
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016021	integral component of membrane
GO:0030666	endocytic vesicle membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR005422 Voltage-dependent calcium channel, gamma-2 subunit
IPR006187 Claudin
IPR008368 Voltage-dependent calcium channel, gamma subunit

PFAM

PF00822
PF13903

PRINTS

PR01602
PR01077
PR01792

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y698