InnateDB Protein
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IDBP-602308.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SOX15
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Protein Name
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SRY (sex determining region Y)-box 15
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Synonyms
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SOX20; SOX26; SOX27;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000439311
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InnateDB Gene
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IDBG-26076 (SOX15)
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Protein Structure
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|
Function |
Binds to the 5'-AACAAT-3' sequence.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.
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Disease Associations |
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Tissue Specificity |
Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. {ECO:0000269PubMed:8978787, ECO:0000269PubMed:9880678}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006325
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chromatin organization
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0008584
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male gonad development
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GO:0014718
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positive regulation of satellite cell activation involved in skeletal muscle regeneration
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GO:0030154
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cell differentiation
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GO:0045843
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negative regulation of striated muscle tissue development
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048627
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myoblast development
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GO:0070318
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positive regulation of G0 to G1 transition
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GO:2000288
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positive regulation of myoblast proliferation
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Cellular Component |
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PDB ID |
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InterPro |
IPR009071
High mobility group box domain
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PFAM |
PF00505
PF09011
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PRINTS |
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PIRSF |
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SMART |
SM00398
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TIGRFAMs |
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Modification |
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SwissProt |
O60248
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PhosphoSite |
PhosphoSite-O60248
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TrEMBL |
B4DWU7
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UniProt Splice Variant |
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Entrez Gene |
6665
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UniGene |
Hs.95582
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RefSeq |
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HUGO |
HGNC:11196
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OMIM |
601297
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CCDS |
CCDS32549
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HPRD |
03191
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IMGT |
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EMBL |
AB006867
AB025355
AC016876
AJ006222
AK301687
BC000985
BC072003
CH471108
X73039
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GenPept |
AAH00985
AAH72003
BAA25663
BAA78784
BAG63159
CAA06920
CAA51520
EAW90156
EAW90157
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