InnateDB Protein
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IDBP-602353.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FXYD6
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Protein Name
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FXYD domain containing ion transport regulator 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000442756
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InnateDB Gene
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IDBG-73337 (FXYD6)
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Protein Structure
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Function |
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
Schizophrenia 2 (SCZD2) [MIM:603342]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269PubMed:17357072}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000272
Ion-transport regulator, FXYD motif
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PFAM |
PF02038
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H0Q3
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PhosphoSite |
PhosphoSite-Q9H0Q3
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TrEMBL |
A0A024R3J8
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UniProt Splice Variant |
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Entrez Gene |
53826
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UniGene |
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RefSeq |
NP_001158309
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HUGO |
HGNC:4030
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OMIM |
606683
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CCDS |
CCDS8387
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HPRD |
09456
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IMGT |
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EMBL |
AK289629
AK290757
AL136699
AL832811
AP000757
AY358976
BC018652
BC093040
BT006717
CH471065
CN310658
CR533457
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GenPept |
AAH18652
AAH93040
AAP35363
AAQ89335
BAF82318
BAF83446
CAB66634
CAG38488
CAI46171
EAW67327
EAW67328
EAW67329
EAW67331
EAW67332
EAW67333
EAW67335
EAW67336
EAW67337
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